Gerosuppression in confluent cells
نویسندگان
چکیده
منابع مشابه
Gerosuppression in confluent cells
The most physiological type of cell cycle arrest - namely, contact inhibition in dense culture - is the least densely studied. Despite cell cycle arrest, confluent cells do not become senescent. We recently described that mTOR (target of rapamycin) is inactive in contact-inhibited cells. Therefore, conversion from reversible arrest to senescence (geroconversion) is suppressed. I this Perspectiv...
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ژورنال
عنوان ژورنال: Aging
سال: 2014
ISSN: 1945-4589
DOI: 10.18632/aging.100714